Levick J R
Arthritis Rheum. 1981 Dec;24(12):1550-60. doi: 10.1002/art.1780241215.
A method is described for the determination of the permeability of the blood-joint barrier to specific plasma proteins, using the ratio of protein concentration in synovial fluid to that in plasma. The inadequacy of the ratio per se as a direct index of permeability is discussed. Permeabilities are evaluated for the normal and rheumatoid human knee. Permeability increases in the rhematoid knee by approximately 6 times for the rheumatoid knee by approximately 6 times for albumin and over 40 times for macroglobulins. The effect of protein molecular dimensions upon permeability is analyzed. Permeability shows less dependence upon solute dimensions in the rheumatoid knee than in the normal knee, i.e., molecular selectivity is reduced. From these data and synovial morphology, a two-membrane model of the blood-joint barrier is developed. The relative contribution of the component intimal and endothelial layers to the total barrier is found to depend upon solute dimensions.
本文描述了一种利用滑液与血浆中蛋白质浓度之比来测定血-关节屏障对特定血浆蛋白通透性的方法。文中讨论了该比值本身作为通透性直接指标的不足之处。评估了正常人和类风湿患者膝关节的通透性。类风湿膝关节中白蛋白的通透性增加约6倍，巨球蛋白的通透性增加超过40倍。分析了蛋白质分子大小对通透性的影响。与正常膝关节相比，类风湿膝关节中通透性对溶质大小的依赖性较小，即分子选择性降低。根据这些数据和滑膜形态，建立了血-关节屏障的双膜模型。发现内膜层和内皮层对总屏障的相对贡献取决于溶质大小。
