Müller-Wiefel D E, Lenhard V, Schärer K
Proc Eur Dial Transplant Assoc. 1981;18:524-30.
In 57 children with chronic renal failure (19 on conservative treatment, 25 haemodialysis and 13 after transplantation) body iron stores were determined by an immunoradiometric assay with a heterologous antibody system in relation to haemochromatosis alleles, HLA A3 and B7. Iron overload, predominantly found during haemodialysis, depended on the number of erythrocyte transfusions given and was found to be more pronounced in patients with HLA A3 and/or B7. The frequency of these antigens was significantly higher in patients with iron overload (91%) than with normal (43%) or decreased (44%) iron stores. The relative risk of iron overload was calculated to be 2.0 for HLA A3 and 8.7 for HLA B7. The results suggest that erythrocyte transfusion therapy should be minimised in children with haemochromatosis alleles in order to avoid organ damage by haemosiderosis.
在57例慢性肾衰竭儿童中（19例接受保守治疗，25例接受血液透析，13例接受移植后），采用异源抗体系统的免疫放射分析方法，针对血色素沉着病等位基因HLA A3和B7测定体内铁储备。铁过载主要见于血液透析期间，取决于红细胞输注次数，且在HLA A3和/或B7患者中更为明显。这些抗原在铁过载患者中的频率（91%）显著高于铁储备正常（43%）或降低（44%）的患者。HLA A3的铁过载相对风险计算为2.0，HLA B7为8.7。结果表明，对于携带血色素沉着病等位基因的儿童，应尽量减少红细胞输血治疗，以避免含铁血黄素沉着症对器官造成损害。
