Weisburger E K
Natl Cancer Inst Monogr. 1981 Dec(58):95-9.
Metabolic experiments have furnished leads on both the detoxification and activation pathways for aromatic amines. These consist largely of C- and N-hydroxylation, followed by conjugation with glucuronic or sulfuric acid, although other mechanisms may be involved. Current emphasis is on the N-hydroxylated derivatives as a precursor to the activated carcinogen. Metabolic patterns have furnished leads in some cases to account for the differences in susceptibility of various species to the carcinogenic aromatic amines, but discrepancies also occur.
代谢实验为芳香胺的解毒和活化途径提供了线索。这些途径主要包括碳和氮的羟基化，随后与葡萄糖醛酸或硫酸结合，不过可能还涉及其他机制。目前的重点是将N - 羟基化衍生物视为活化致癌物的前体。在某些情况下，代谢模式为解释不同物种对致癌芳香胺易感性的差异提供了线索，但也存在差异。
