Karring M, Pohjanvirta R, Rahko T, Korpela H
Acta Vet Scand. 1981;22(3-4):289-95. doi: 10.1186/BF03548654.
The effect of molybdenum (Mo) and copper (Cu) supplementation on some blood parameters and trace elements of tissues of cocks was investigated. The animals were fed with commercial poultry feed and water ad libitum and the experimental groups received peroral supplementation of different amounts of Mo or Cu during 4 weeks. Lowered values of serum uric acid were established in animals receiving 400 µg supplementation of either Mo or Cu. In contrast, the cocks receiving 100 µg supplementation of Cu displayed elevated concentrations of uric acid in the serum. A very significant statistical difference was noted between the uric acid levels of the animals receiving either moderate (group IV) or excess (group V) supplementation of Cu. The cocks with an excess of Cu displayed lowered hemoglobin and hematocrit values but no signs of Cu-intoxication were found in macro- and microscopical studies. Atomic absorption spectrophotometry was employed in the determinations of the content of Mo, Cu, Zn, Mn, Fe and & in the liver and kidneys of the cocks. The authors suggest that the results of the trace element analyses presented are to be considered as preliminary values. Furthermore, the effect of Mo and Cu on uric acid metabolism should be additionally clarified by applying histochemical studies on xanthine oxidase in different tissues of cocks in order to make conclusions on the significance of Mo and Cu in the etiology of avian gout.
研究了补充钼（Mo）和铜（Cu）对公鸡某些血液参数及组织微量元素的影响。动物自由采食商业家禽饲料和饮水，实验组在4周内接受不同剂量的Mo或Cu口服补充。接受400μg Mo或Cu补充的动物血清尿酸值降低。相反，接受100μg Cu补充的公鸡血清尿酸浓度升高。接受中等剂量（IV组）或过量剂量（V组）Cu补充的动物尿酸水平之间存在非常显著的统计学差异。Cu过量的公鸡血红蛋白和血细胞比容值降低，但在宏观和微观研究中未发现Cu中毒迹象。采用原子吸收分光光度法测定公鸡肝脏和肾脏中Mo、Cu、Zn、Mn、Fe和&的含量。作者认为所呈现的微量元素分析结果应被视为初步值。此外，应通过对公鸡不同组织中的黄嘌呤氧化酶进行组织化学研究，进一步阐明Mo和Cu对尿酸代谢的影响，以便就Mo和Cu在禽痛风病因学中的意义得出结论。
