Okamoto M, Miyatake K, Kinoshita N, Matsuhisa M, Nakasone I, Nagata S, Sakakibara H, Nimura Y
J Cardiogr. 1981 Dec;11(4):1291-301.
Blood flows in the main pulmonary artery, right pulmonary artery and right ventricular outflow tract were analyzed in 11 cases of valvular pulmonary stenosis and 10 healthy subjects by pulsed echo Doppler cardiography (two-dimensional) with the parasternal and suprasternal approaches. 1) The systolic flow in the right pulmonary artery was detected in 7 cases of valvular pulmonary stenosis, in which the flow of both right and main pulmonary arteries was detected in only one case. The flows seemed to be turbulent. These abnormal signals were never detected in healthy subjects and considered to be caused by the narrowing of the pulmonic orifice. 2) Abnormal flow signals were also detected in the right ventricular outflow tract in patients of pulmonary stenosis. Their features were as follows: (1) A systolic turbulent flow was detected in a case with severe hypertrophy of the wall and narrowing of the lumen of the right ventricular outflow tract. (2) A/S ratio, which is a ratio of the peak velocity in atrial contraction (A) to the peak velocity in systole (S), was larger in cases with pulmonary stenosis than in healthy subjects (p less than 0.05). It was considered that the atrial component in the right ventricular filling was augmented in pulmonary stenosis. (3) The PEP/ET (pre-ejection period/ejection time) of the right ventricle was smaller in cases with pulmonary stenosis than in healthy subjects (p less than 0.05). The ratio exhibited a reverse correlation with the pressure gradient between the right ventricle and pulmonary artery (r = 0.74, p less than 0.025). (4) Acceleration time index, a ratio of the time interval between the upstroke and the peak velocity of ejection flow to the ejection time, as a parameter indicating the time delay of the peak velocity exhibited a significant correlation with the pressure gradient between the right ventricle and pulmonary artery (r = 0.67, p less than 0.05). (5) No correspondence was revealed between the time interval of Q-peak velocity in systole and that of Q-peak intensity of the murmur during systole. It was remained to be clarified.
采用胸骨旁和胸骨上窝切面的二维脉冲回声多普勒心动图,对11例瓣膜型肺动脉狭窄患者和10名健康受试者的主肺动脉、右肺动脉及右心室流出道的血流情况进行了分析。1)在7例瓣膜型肺动脉狭窄患者中检测到右肺动脉的收缩期血流,其中仅1例同时检测到右肺动脉和主肺动脉的血流。这些血流似乎呈湍流状态。在健康受试者中从未检测到这些异常信号,认为是由肺动脉口狭窄所致。2)肺动脉狭窄患者的右心室流出道也检测到异常血流信号。其特征如下:(1)在1例右心室流出道壁严重肥厚且管腔狭窄的患者中检测到收缩期湍流。(2)肺动脉狭窄患者心房收缩期峰值速度(A)与收缩期峰值速度(S)之比(A/S比值)高于健康受试者(p<0.05)。认为肺动脉狭窄时右心室充盈中的心房成分增加。(3)肺动脉狭窄患者右心室的射血前期/射血时间(PEP/ET)低于健康受试者(p<0.05)。该比值与右心室和肺动脉之间的压力阶差呈负相关(r = 0.74,p<0.025)。(4)加速时间指数,即射血血流上升至峰值速度的时间间隔与射血时间之比,作为表示峰值速度延迟的参数,与右心室和肺动脉之间的压力阶差呈显著相关(r = 0.67,p<0.05)。(5)收缩期Q峰速度的时间间隔与收缩期杂音Q峰强度的时间间隔之间未发现对应关系。这一点仍有待阐明。