性激素、催乳素和绒毛膜促性腺激素对豚鼠松果体电活动的影响。
The effects of sex hormones, prolactin, and chorionic gonadotropin on pineal electrical activity in guinea pigs.
作者信息
Semm P, Demaine C, Vollrath L
出版信息
Cell Mol Neurobiol. 1981 Sep;1(3):259-69. doi: 10.1007/BF00710681.
Abstract
Microelectrophoretic application of sex hormones onto pineal cells in guinea pigs has shown different responses in pregnant females as compared to males. In pregnant females estrone caused excitation in 74% of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of the cells. In contrast, in males estrone caused excitation of only 19% but inhibition of 37%. A smaller percentage of cells was inhibited by progesterone, while the predominant response to testosterone was excitation. These results suggest that the pineal gland may be under a feedback control.
摘要
对豚鼠松果体细胞进行性激素的微电泳施加实验，结果表明，与雄性相比，怀孕雌性的反应有所不同。在怀孕雌性中，雌酮在74%的受试细胞中引起兴奋，而孕酮、睾酮、催乳素和人绒毛膜促性腺激素在大多数受试细胞中起抑制作用；相比之下，在雄性中，雌酮仅在19%的细胞中引起兴奋，但在37%的细胞中起抑制作用。受孕酮抑制的细胞比例较小，而对睾酮的主要反应是兴奋。这些结果表明，松果体可能受到反馈控制。
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