Young W, Tomasula J, DeCrescito V, Flamm E S, Ransohoff J
J Neurosurg. 1980 Jan;52(1):64-72. doi: 10.3171/jns.1980.52.1.0064.
Vestibulospinal tract function was monitored in experimental contusion of the spinal cord in cats, and compared with somatosensory cortical evoked potentials. Both white and gray matter portions of the vestibular and somatosensory pathways were evaluated in cord injuries at T-7 and L-4. Severe contusions of 20 gm-20 cm force impact resulted in a rapid (less than 1 second) abolition of thoracic white matter conductivity, but a somewhat slower (4 to 5 minutes) loss of lumbar gray matter responses. A paradoxical transient recovery of white matter conductivity occurred 1 to 2 hours after injury, despite eventual progression to central hemorrhagic necrosis at the contusion site. In contrast, mild contusions (20 gm-10 cm force impact) produced only a temporary loss of neuronal activity: white matter for 1 to 2 hours, and gray matter for 30 to 40 minutes. In general, vestibular and somatosensory potentials showed similar sensitivity to contusion, although the former tended to recover earlier. We conclude that contusion injury causes two types of neuronal dysfunction in spinal cord: 1) a low-threshold concussion-related loss of activity lasting 30 to 120 minutes; and 2) a higher threshold necrotic process, requiring 1 to 2 hours to develop, which apparently spreads from gray to white matter.
在猫脊髓实验性挫伤中监测前庭脊髓束功能，并与体感皮层诱发电位进行比较。在T-7和L-4脊髓损伤中评估前庭和体感通路的白质和灰质部分。20克-20厘米力冲击的严重挫伤导致胸段白质传导性迅速（不到1秒）消失，但腰段灰质反应丧失稍慢（4至5分钟）。尽管损伤部位最终进展为中央出血性坏死，但损伤后1至2小时白质传导性出现矛盾的短暂恢复。相比之下，轻度挫伤（20克-10厘米力冲击）仅导致神经元活动暂时丧失：白质为1至2小时，灰质为30至40分钟。一般来说，前庭和体感电位对挫伤表现出相似的敏感性，尽管前者往往恢复得更早。我们得出结论，挫伤性损伤在脊髓中导致两种类型的神经元功能障碍：1）与低阈值震荡相关的活动丧失，持续30至120分钟；2）较高阈值的坏死过程，需要1至2小时发展，显然从灰质扩散到白质。
