Niebrój-Dobosz I, Fidziańska A, Rafałowska J, Sawicka E
Acta Neuropathol. 1980;49(2):145-52. doi: 10.1007/BF00690754.
Biochemical, light and electron microscopic observations in six human fetuses between the 16th and 34th weeks of gestation and five infants, 1 day to 3 years old, are presented. The results indicate that myelination of the human spinal cord started before the 16th week of gestation, as a considerable amount of myelin is isolated at this time biochemically, and occasionally axons with loose myelin coils are observed in the electron microscope. It is also stressed that morphological studies are insufficient to evaluate the completion time of the myelination process, as it can be shown biochemically that qualitative myelin maturation takes a long time.
本文呈现了对6例妊娠16至34周的人类胎儿以及5例1日龄至3岁婴儿的生化、光学和电子显微镜观察结果。结果表明，人类脊髓的髓鞘形成在妊娠16周之前就已开始，因为此时通过生化方法可分离出相当数量的髓磷脂，并且在电子显微镜下偶尔能观察到带有松散髓鞘螺旋的轴突。还强调了形态学研究不足以评估髓鞘形成过程的完成时间，因为生化研究表明髓磷脂的定性成熟需要很长时间。
