Wynne J, Mann T, Alpert J S, Green L H, Grossman W
JAMA. 1980 Apr 11;243(14):1440-2.
To assess the effects of nitrous oxide on hemodynamics and left ventricular function in man, 30 patients (24 of whom had coronary artery disease) were studied at the time of cardiac catheterization. Left ventricular peak-systolic pressure and end-diastolic volume showed no significant change during nitrous oxide inhalation. The maximum rate of pressure rise declined slightly, but left ventricular end-diastolic pressure and ejection fraction were unchanged. Heart rate and cardiac index declined modestly. The pressure-rate product and left ventricular minute work index decreased, suggesting a decline in myocardial oxygen requirements. These data suggest that nitrous oxide inhalation does not produce important depression of left ventricular performance. The consistent decrease in the determinants of myocardial oxygen demand suggests that use of this analgesic agent may be helpful in patients with coronary heart disease.
为评估一氧化二氮对人体血流动力学和左心室功能的影响，在心脏导管插入术时对30例患者（其中24例患有冠状动脉疾病）进行了研究。吸入一氧化二氮期间，左心室收缩压峰值和舒张末期容积无显著变化。压力上升的最大速率略有下降，但左心室舒张末期压力和射血分数未改变。心率和心脏指数略有下降。压力-心率乘积和左心室每分钟作功指数降低，提示心肌需氧量下降。这些数据表明，吸入一氧化二氮不会对左心室功能产生重要抑制作用。心肌需氧量决定因素的持续下降表明，使用这种镇痛剂可能对冠心病患者有益。
