Freeman R R, Trejdosiewicz A J, Cross G A
Nature. 1980 Mar 27;284(5754):366-8. doi: 10.1038/284366a0.
Immunity to malaria is mediated, at least in part, by antibody. Resistance to infection has been passively transferred with immune serum or its immunoglobulin fraction in human, simian and rodent malaria. However, because of the structural and antigenic complexity of the malaria parasites, it has proved difficult to identify and characterise those parasite antigens against which protective antibody is directed. We have produced several hybrid cell lines secreting monoclonal antibodies against the rodent malaria parasite, Plasmodium yoelii, and we now report that, of the antibodies tested, only those specific for antigens exclusive to the merozoite were protective in passive transfer experiments. Other anti-P. yoelii monoclonal antibodies, apparently recognising antigens in the membrane of the infected erythrocyte, were not protective on passive transfer. The protective monoclonal antibodies should be useful in the isolation of the important antigens of this parasite.
疟疾免疫至少部分是由抗体介导的。在人类、猿类和啮齿类疟疾中，免疫血清或其免疫球蛋白组分已被动转移了对感染的抵抗力。然而，由于疟原虫的结构和抗原复杂性，已证明难以鉴定和表征保护性抗体所针对的那些寄生虫抗原。我们已经产生了几种分泌针对啮齿类疟原虫约氏疟原虫的单克隆抗体的杂交细胞系，并且我们现在报告，在测试的抗体中，只有那些对裂殖子特有的抗原具有特异性的抗体在被动转移实验中具有保护作用。其他抗约氏疟原虫单克隆抗体，显然识别感染红细胞膜中的抗原，在被动转移时没有保护作用。保护性单克隆抗体应该有助于分离这种寄生虫的重要抗原。
