Fox K, Welman E, Selwyn A
Am J Cardiol. 1980 Apr;45(4):769-74. doi: 10.1016/0002-9149(80)90120-4.
The effects of propranolol on myocardial perfusion and metabolism during acute myocardial infarction were studied in 18 mongrel dogs. A reversible snare was placed on the left anterior descending coronary artery; regional myocardial perfusion was continuously measured using the short-lived isotope krypton-81m, and myocardial metabolism was assessed using the epicardial electrocardiogram and measurement of release of creatine kinase activity from the affected segment of myocardium. Six dogs with no arterial occlusion acted as "sham operated" dogs; six others in which the snare was occluded acted as a control group and a third group of six were given propranolol, 0.5 mg/kg, 30 minutes after coronary occlusion. All variables were recorded before and for 5 hours after coronary occlusion. Dogs treated with propranolol showed a significant improvement in regional myocardial perfusion to the affected segment, decreased loss of electrically active myocardium at the end of each experiment for any given degree of early S-T segment elevation and a delay in the local release of creatine kinase activity compared with that in the control dogs. These results suggest that propranolol exerts a beneficial effect on the progress of ischemic myocardial damage when given shortly after the onset of infarction.
在18只杂种狗身上研究了普萘洛尔对急性心肌梗死期间心肌灌注和代谢的影响。在左前降支冠状动脉上放置一个可逆圈套器；使用短寿命同位素氪-81m连续测量局部心肌灌注，并通过体表心电图和测量梗死心肌节段肌酸激酶活性的释放来评估心肌代谢。6只未进行动脉闭塞的狗作为“假手术”狗；另外6只圈套器闭塞的狗作为对照组，第三组6只在冠状动脉闭塞30分钟后给予0.5mg/kg普萘洛尔。记录冠状动脉闭塞前及闭塞后5小时的所有变量。与对照组相比，接受普萘洛尔治疗的狗梗死节段局部心肌灌注有显著改善，在每个实验结束时，对于任何给定程度的早期S-T段抬高，电活动心肌的损失减少，肌酸激酶活性的局部释放延迟。这些结果表明，在梗死发作后不久给予普萘洛尔，对缺血性心肌损伤的进展有有益作用。
