诺米芬辛（阿立凡、美利他）的代谢：从人尿中分离并鉴定诺米芬辛 - 14C 的结合物
Metabolism of nomifensine (Alival, Merital): isolation and identification of the conjugates of nomifensine-14C from human urine.
作者信息
Hornke I, Fehlhaber H W, Girg M, Jantz H
出版信息
Br J Clin Pharmacol. 1980 Mar;9(3):255-64. doi: 10.1111/j.1365-2125.1980.tb04835.x.
Abstract
1 It can be stated in regard to the metabolism of nomifensine that the metabolites and also the starting compound are present in alkaline urine almost completely in conjugated form. 2 The metabolites M I-M III represent about 30% of the radioactivity excreted with urine. Two-thirds are N-glucuronides and one-third O-glucuronides. 3 Nearly the entire remainder of the renally eliminated radioactivity in nomifensine which is present in conjugated form as N-glucuronide. 4 Thus over 90% of the metabolites formed in man and excreted via urine have been identified.
摘要
- 关于诺米芬辛的代谢可以指出，其代谢产物以及起始化合物在碱性尿液中几乎完全以结合形式存在。2. 代谢产物M I - M III约占随尿液排出的放射性的30%。其中三分之二是N - 葡萄糖醛酸苷，三分之一是O - 葡萄糖醛酸苷。3. 诺米芬辛经肾脏排泄的放射性物质几乎全部以N - 葡萄糖醛酸苷的结合形式存在。4. 因此，已鉴定出在人体中形成并经尿液排出的代谢产物超过90%。
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Metabolism of nomifensine (Alival, Merital): isolation and identification of the conjugates of nomifensine-14C from human urine.诺米芬辛（阿立凡、美利他）的代谢：从人尿中分离并鉴定诺米芬辛 - 14C 的结合物
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本文引用的文献
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[8-amino-4-phenyl-1,2,3,4-tetrahydroisoquinolines, a new group of antidepressive psycholeptic drugs].[8-氨基-4-苯基-1,2,3,4-四氢异喹啉类，一类新型抗抑郁精神抑制药]
Arzneimittelforschung. 1971 Jul;21(7):1045.
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8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant.8-氨基-2-甲基-4-苯基-1,2,3,4-四氢异喹啉，一种新型抗抑郁药。
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Mass spectral analysis of glucuronides.葡萄糖醛酸苷的质谱分析。
J Med Chem. 1973 Jan;16(1):30-3. doi: 10.1021/jm00259a009.
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[Results of an open and a double-blind study of nomifensin in comparison to imipramin (author's transl)].与丙咪嗪相比，诺米芬辛的开放和双盲研究结果（作者译）
Arch Psychiatr Nervenkr (1970). 1974;219(3):265-76. doi: 10.1007/BF00342052.
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Metabolism of nomifensine in man and animal species.诺米芬辛在人和动物物种中的代谢。
Arzneimittelforschung. 1978;28(1):58-64.
6
Kinetics and metabolism of nomifensine in animals.诺米芬辛在动物体内的动力学与代谢
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):109S-116S. doi: 10.1111/j.1365-2125.1977.tb05736.x.
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