Methotrexate in psoriasis. A brief review of indications, usage, and complications of methotrexate therapy.

Hanno R, Gruber G G, Owen L G, Callen J P

J Am Acad Dermatol. 1980 Feb;2(2):171-4. doi: 10.1016/s0190-9622(80)80398-7.

Methotrexate is widely used by dermatologists in the treatment of recalcitrant psoriasis. Despite potentially serious side effects, including hepatic cirrhosis, the drug is relatively safe and remarkably effective when carefully administered to selected patients.