每日一次口服去甲替林治疗内源性抑郁症患者的疗效及副作用。

Therapeutic effect and side effects in patients with endogenous depression treated with oral nortriptyline once a day.

作者信息

Pedersen J H, Sørensen J L

出版信息

Neuropsychobiology. 1980;6(1):42-7. doi: 10.1159/000117731.

Abstract

Out of 24 patients with endogenous depression, 21 completed the treatment with nortriptyline 150 mg as once-a-day dosage. The therapeutic effect was good and at any rate not inferior to that of dosages several times a day. Side effects were only little pronounced and at any rate not more marked than after dosages several times a day. Out of regard for the administrative and psychological advantages of the once-a-day dosage this form should be preferred, not least in the out-patient treatment with nortriptyline of endogenous depression.

摘要

在24例内源性抑郁症患者中，21例完成了用每日一次剂量150毫克去甲替林的治疗。治疗效果良好，无论如何都不逊色于一日多次给药的剂量。副作用仅轻微明显，无论如何都不比一日多次给药后更显著。考虑到一日一次给药剂量在管理和心理方面的优势，这种给药方式应被优先选用，尤其是在门诊治疗内源性抑郁症使用去甲替林时。