Kirkpatrick J R, Bouwman D L
Surg Gynecol Obstet. 1980 May;150(5):683-6.
Until recently, the Graham patch was the undisputed method of management for a perforated duodenal ulcer. Results of our experience with 186 patients treated at Wayne State University Affiliated Hospitals from 1970 through 1978 dispute this concept and suggest that a definitive operation is the procedure of choice. One hundred and thirty-seven of the patients were treated with an omental patch, and 47 underwent a definitive operation; 114 of the patients were available for an 18 month follow-up study. It was found that previous ulcer symptoms were not an accurate predictor of the need for a subsequent definitive operation and that mortality was determined by the age and condition of the patient at the time of operation rather than by the choice of operation itself. It is recommended that the perforation itself is an indication for a definitive operation unless the patient is in a state of shock at the time of operation. Vagotomy and pyloroplasty have proved to be safe, reliable, definitive operations in this situation.
直到最近,格雷厄姆补片法一直是治疗十二指肠溃疡穿孔无可争议的方法。我们在1970年至1978年期间对韦恩州立大学附属医院收治的186例患者的治疗经验结果对这一观念提出了质疑,并表明确定性手术是首选术式。其中137例患者接受了网膜补片治疗,47例接受了确定性手术;114例患者可进行为期18个月的随访研究。结果发现,既往溃疡症状并不能准确预测后续是否需要进行确定性手术,死亡率取决于手术时患者的年龄和状况,而非手术方式本身。建议除非患者在手术时处于休克状态,否则穿孔本身即表明需要进行确定性手术。在这种情况下,迷走神经切断术和幽门成形术已被证明是安全、可靠的确定性手术。