糖和氨基酸在豚鼠小肠中的转运。

Transport of sugars and amino acids across guinea pig small intestine.

作者信息

Munck B G

出版信息

Biochim Biophys Acta. 1980 Apr 10;597(2):411-7. doi: 10.1016/0005-2736(80)90117-0.

Abstract

Using guinea pig small intestine for measurements of influx across the brush border membrane (Jmc), unidirectional transmural fluxes (Jms,Jsm), and steady-state epithelial uptake [A]c, the characteristics of the mutual inhibition were examined. The mutual inhibition of Jmc was in the range of 9--16%, and appeared to be sodium dependent, Jms and [A]c were inhibited by at least 40%, and Jsm was unaffected. All the results can be explained in terms of therheogenic version of the sodium gradient hypothesis. Whereas only the mutual inhibition of Jmc can also be explained in terms of allosteric interactions between the binding sites for sugars and amino acids.

摘要

利用豚鼠小肠来测量跨刷状缘膜的内流（Jmc）、单向跨膜通量（Jms、Jsm）以及稳态上皮摄取量[A]c，对相互抑制的特性进行了研究。Jmc的相互抑制范围为9%-16%，且似乎依赖于钠，Jms和[A]c至少被抑制40%，而Jsm未受影响。所有结果都可以用钠梯度假说的生电版本来解释。而只有Jmc的相互抑制也可以用糖和氨基酸结合位点之间的变构相互作用来解释。