通过曼尼希碱缩合反应合成γ-羧基谷氨酸及其衍生物。
Synthesis of gamma-carboxyglutamic acid and its derivatives via Mannich-base condensation.
作者信息
Juhász A, Bajusz S
出版信息
Int J Pept Protein Res. 1980 Feb;15(2):154-8. doi: 10.1111/j.1399-3011.1980.tb02562.x.
Abstract
This report describes the synthesis of N alpha-formyl and N alpha-benzyloxycarbonyl-gamma, gamma-di-t-butyl-gamma-carboxyglutamic acid via Mannich-base condensation starting from di-t-butyl malonate and diethylformamido or benzyloxycarbonylamidomalonate.
摘要
本报告描述了从丙二酸二叔丁酯和二乙基甲酰胺或苄氧羰基酰胺丙二酸酯出发，通过曼尼希碱缩合反应合成Nα-甲酰基和Nα-苄氧羰基-γ,γ-二叔丁基-γ-羧基谷氨酸的方法。
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