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无束缚大鼠的慢性动静脉通路

Chronic arterial and venous access in the unrestrained rat.

作者信息

Burt M E, Arbeit J, Brennan M F

出版信息

Am J Physiol. 1980 Apr;238(4):H599-603. doi: 10.1152/ajpheart.1980.238.4.H599.

DOI:10.1152/ajpheart.1980.238.4.H599
PMID:7377334
Abstract

A system is described for chronic cannulation of the thoracic aorta and superior vena cava in the rat. This system employs a protective stainless steel coiled spring and water tight swivel and allows chronic infusion of solutions and simultaneous intermittent blood sampling for prolonged periods of time in the undisturbed unanesthetized rat. The rats (200-250 g) lost approximately 25 g in the immediate postoperative period, but then gained weight at a relatively normal rate (cannulated rats, 2.23 g/day; control rats, 2.29 g/day).

摘要

描述了一种用于大鼠胸主动脉和上腔静脉慢性插管的系统。该系统采用保护性不锈钢螺旋弹簧和防水旋转接头,可在未受干扰的未麻醉大鼠中长期进行溶液的慢性输注和同步间歇性血液采样。大鼠(200 - 250克)在术后即刻体重减轻约25克,但随后以相对正常的速率增重(插管大鼠,2.23克/天;对照大鼠,2.29克/天)。

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