新型支气管扩张剂三甲喹醇对牛肺静脉的作用。

Actions of the novel bronchodilator, trimetaquinol, on bovine pulmonary vein.

作者信息

Hanna C J, Hambleton A, Eyre P

出版信息

Can J Physiol Pharmacol. 1980 Jan;58(1):101-3. doi: 10.1139/y80-018.

Abstract

The actions of the beta-sympathomimetic bronchodilator trimetaquinol (TMQ) were examined on bovine pulmonary vein smooth muscle in vitro. TMQ partially and reversibly inhibited 5-hydroxytryptamine (5HT) induced contractions of the vein strips. The relaxant activity was neither blocked by propranolol (10(-7) M) nor enhanced by phentolamine (10(-7) M). Isoproterenol, alone or in the presence of phentolamine (10(-7) M), was much less effective than TMQ in relaxing 5HT-induced contractions. From these results it is suggested that TMQ functions via a "non-beta-adrenergic" mechanism to relax bovine pulmonary vein smooth muscle.

摘要

在体外对牛肺静脉平滑肌研究了β-拟交感神经支气管扩张剂三甲醌（TMQ）的作用。TMQ部分且可逆地抑制5-羟色胺（5HT）诱导的静脉条收缩。松弛活性既不被普萘洛尔（10⁻⁷M）阻断，也不被酚妥拉明（10⁻⁷M）增强。单独使用异丙肾上腺素或在酚妥拉明（10⁻⁷M）存在的情况下，在松弛5HT诱导的收缩方面比TMQ效果差得多。从这些结果表明，TMQ通过“非β-肾上腺素能”机制发挥作用以松弛牛肺静脉平滑肌。