谷胱甘肽S-转移酶对微粒体介导的黄曲霉毒素B1与DNA结合的抑制作用。
Inhibition of microsome-mediated binding of aflatoxin B1 to DNA by glutathione S-transferase.
作者信息
Lotlikar P D, Insetta S M, Lyons P R, Jhee E C
出版信息
Cancer Lett. 1980 Apr;9(2):143-9. doi: 10.1016/0304-3835(80)90118-4.
PMID:7379043
Abstract
Hamster liver microsome-mediated [14C]aflatoxin B1 binding to DNA is inhibited by 105,000 X g liver supernatant fraction. Absolute requirement of glutathione for the inhibitory activity of the dialyzed supernatant and irreversible loss of the inhibitory activity by the heat-treated supernatant indicate involvement of glutathione S-transferase. Concomitant with inhibition of aflatoxin B1-DNA binding, the formation of an aflatoxin B1-glutathione conjugate is indicated.
摘要
仓鼠肝微粒体介导的[14C]黄曲霉毒素B1与DNA的结合受到105,000×g肝脏上清液组分的抑制。透析后的上清液的抑制活性对谷胱甘肽有绝对需求，且热处理后的上清液的抑制活性不可逆丧失，这表明谷胱甘肽S-转移酶参与其中。与黄曲霉毒素B1-DNA结合的抑制同时，还表明形成了黄曲霉毒素B1-谷胱甘肽缀合物。
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