视神经受压期间的髓鞘再生。

Remyelination during optic nerve compression.

作者信息

Clifford-Jones R E, Landon D N, McDonald W I

出版信息

J Neurol Sci. 1980 May;46(2):239-43. doi: 10.1016/0022-510x(80)90082-9.

Abstract

The structural changes produced in cat optic nerve by incremental chronic compression have been investigated by light and electron microscopy. Within the first week extensive demyelination occurred; some fibres underwent Wallerian degeneration and there was marked proliferation of astrocytic processes. After 5 weeks of compression remyelinated fibres were seen and occurred in all longer-term animals despite the maintenance of compression, but some partially and completely demyelinated fibres persisted. Myelin thickness had not returned to normal in the remyelinated fibres after 19 weeks and was often strikingly variable. The significance of these observations is discussed in the light of the recent demonstration of the restoration of central conduction by remyelination.

摘要

通过光学显微镜和电子显微镜研究了猫视神经因渐进性慢性压迫所产生的结构变化。在第一周内发生了广泛的脱髓鞘；一些纤维发生了华勒氏变性，并且星形细胞突起有明显增生。压迫5周后可见到再髓鞘化纤维，并且在所有长期受压的动物中均出现，尽管压迫仍在持续，但一些部分和完全脱髓鞘的纤维依然存在。19周后再髓鞘化纤维的髓鞘厚度未恢复正常，且常常差异显著。根据最近关于再髓鞘化恢复中枢传导的研究结果，对这些观察结果的意义进行了讨论。