己烯雌酚对24小时血浆睾酮水平的影响：比较每日1毫克和5毫克剂量以及每日3次每次1毫克剂量的研究。

Effect of diethylstilbestrol on plasma testosterone levels during 24 hours: study comparing doses of 1 and 5 mg. daily, and 1 mg. 3 times daily.

作者信息

Flores-Esteva J, Medina-Santillán R, Berea-Domínguez H, Villalpando-Casas J J, Martínez-Romero M A, Navarrete L R, Martin-Lombard M E

出版信息

J Urol. 1980 Jun;123(6):887-9. doi: 10.1016/s0022-5347(17)56179-0.

DOI:10.1016/s0022-5347(17)56179-0

PMID:7382007

Abstract

A study was done on 30 patients with advanced adenocarcinoma of the prostate treated with diethylstilbestrol. Three groups of patients were given daily doses of 1, 5, and 1 times 3 mg. diethylstilbestrol, respectively. The study was confined to the effects of treatment on the levels of plasma testosterone by taking hormonal specimens every 4 hours for 24 hours. The results showed little difference of plasma testosterone among the groups under study and a statistical analysis showed no significant differences. Therefore, our study showed no appreciable advantage in the dosage spread over the day, compared to commonly used doses of 1 or 5 mg. diethylstilbestrol given in a single dosage.

摘要

对30例接受己烯雌酚治疗的晚期前列腺腺癌患者进行了一项研究。三组患者分别每日给予1毫克、5毫克和1×3毫克的己烯雌酚。该研究通过在24小时内每4小时采集激素样本，来观察治疗对血浆睾酮水平的影响。结果显示，研究中的各组血浆睾酮水平差异不大，统计分析表明无显著差异。因此，与单次给予常用剂量1毫克或5毫克己烯雌酚相比，我们的研究表明，一天内分剂量给药并无明显优势。