Meduri F, Ferrazzani S, Bennici S, Moneta E, Grilli M, Savi L, Pola P
Minerva Med. 1980 May 19;71(20):1443-51.
Chemical determination of total and esterified cholesterol and electrophoretic separation of plasma lipoproteins was carried out in a chemico-clinical approach to the pathology of lipide metabolism in pregnancy. In a future study, the investigation will be extended to the neonatal aspect of the problem. 136 women were studied, with 446 samples being taken, specifically: 65 controls, i.e. pregnant women not presenting pathology that might obviously involve lipide metabolism, 36 hypertense pregnant women, 28 diabetic and 7 with gravidic hepatosis. Observation of the data confirms that in pregnancy there is a steady, meaningful increase in cholesterolaemia and that the electrophoretic picture shows a steady reduction in alpha-lipoproteins, with stimulatneous increase in pre-beta proteins, reaching a peak in hepatosis cases, and an increase in beta lipoproteins. All this agrees with functional and teleological modifications in lipide metabolism during gestation.
采用化学临床方法对妊娠期脂质代谢病理进行研究，测定了总胆固醇和酯化胆固醇，并对血浆脂蛋白进行了电泳分离。在未来的研究中，将把调查扩展到该问题的新生儿方面。对136名女性进行了研究，共采集了446份样本，具体如下：65名对照组，即未出现明显涉及脂质代谢病理的孕妇；36名高血压孕妇；28名糖尿病孕妇；7名妊娠肝病患者。对数据的观察证实，妊娠期胆固醇血症稳步且显著增加，电泳图谱显示α脂蛋白稳步减少，前β蛋白同时增加，在肝病患者中达到峰值，β脂蛋白也增加。所有这些都与妊娠期脂质代谢的功能和目的论改变相符。
