庚二酰辅酶A的合成

Synthesis of pimeloyl coenzyme A.

作者信息

Chauhan M S, Dakshinamurti K

出版信息

Prep Biochem. 1980;10(2):167-71. doi: 10.1080/00327488008061732.

Abstract

Synthesis of pimeloyl CoA based on the reaction of N-hydroxysuccinimide ester of pimelic acid and coenzyme A in the presence of sodium hydroxide is reported. The CoA derivative has been isolated, purified and fully characterized from its chemical properties and spectral data. The yields are superior to acid chloride, anhydride or ester exchange methods due to lack of side reactions.

摘要

报道了基于庚二酸N - 羟基琥珀酰亚胺酯与辅酶A在氢氧化钠存在下的反应合成庚二酰辅酶A。已从其化学性质和光谱数据中分离、纯化并充分表征了该辅酶A衍生物。由于没有副反应，产率优于酰氯、酸酐或酯交换法。