Ozawa A, Sawamura S, Nagao T, Sasaki S
Tokai J Exp Clin Med. 1980 Jan;5(1):97-112.
The present results of investigations performed on fresh fecal samples from a healthy adult and subjects with acute leukemia cultured bacteriologically using both aerobic and anaerobic techniques have led to the following conclusions. 1) In studies on the intestinal bacterial flora of the subjects examined, obligate anaerobic bacteria rather than facultative anaerobes accounted for more than 99% of the microorganisms. 2) Although some qualitative differences seem to exist between fecal bacterial flora components of the normal individual and leukemia patients examined, further investigations considering various factors controlling and influencing the composition of intestinal bacterial flora are needed to evaluate the results obtained. 3) The results obtained herein indicate that changes in intestinal bacterial flora induced by non-absorbable antibiotics are associated with the host defense mechanisms. 4) The relative predominance of aerobic versus anaerobic bacterial flora in the intestine may reflect the degree of severity of clinical manifestation in leukemia patients. In the data obtained from the present investigations, the predominating fecal anaerobic bacteria may serve as a base line for the evaluation and interpretation of the host defense system by patterns of the components of bowel flora brought about by internal or external environmental changes.
对一名健康成年人以及患有急性白血病的受试者的新鲜粪便样本采用需氧和厌氧技术进行细菌培养的当前研究结果得出了以下结论。1）在所检查受试者的肠道细菌菌群研究中，专性厌氧菌而非兼性厌氧菌占微生物的99%以上。2）尽管正常个体和所检查的白血病患者的粪便细菌菌群成分之间似乎存在一些定性差异，但需要进一步考虑控制和影响肠道细菌菌群组成的各种因素的研究来评估所获得的结果。3）本文获得的结果表明，不可吸收抗生素诱导的肠道细菌菌群变化与宿主防御机制有关。4）肠道中需氧菌与厌氧菌菌群的相对优势可能反映白血病患者临床表现的严重程度。在本次研究获得的数据中，占主导地位的粪便厌氧菌可作为通过内部或外部环境变化引起的肠道菌群成分模式来评估和解释宿主防御系统的基线。
