Grimm L, Bircher J, Preisig R
Z Gastroenterol. 1980 Jan;18(1):45-56.
The paper describes a modification of the galactose breath test (GBT) for assessing liver function. Following iv injection of 0.5 g galactose per kg body weight, together with 2 mu Ci generally 14C-labelled galactose, 14CO2 is collected in regular intervals during one hour. Since 14C-activity in breath exhibits a linear rise during 70--100 minutes, the curve obtained permits calculation of an initial slope, as well as the "standardized specific activity" after 45 min GBT was performed in 8 liver normals, 8 alcoholic cirrhotics, 4 patients with chronic active hepatitis (CAH) and 6 with primary biliary cirrhosis (PBC). The results were compared with the simultaneously measured galactose elimination capacity (GEC) and the initial plasma disappearance (ki) of bromsulphthalein (BSP). In the liver normals, the values for initial slope and standardized specific activity were 1.08 +/- S.D. 0.3 and 0.42 +/- S.D. 0.1, respectively. In comparison, the values obtained in all patients groups were markedly reduced. CAH patients exhibited the most severe decrease; the reduction was smallest in PBC patients. The GBT discriminated well between liver normals and patients with liver disease (p less than 0.001, t-test). The results of the GBT correlated linearly with GEC (r = 0.86 and 0.87, respectively) and with BSP-ki (r = 0.9 and 0.92, respectively). These results suggest that the GBT may be regarded as a quantitative measure of a cystosolic hepatic function.
本文描述了一种用于评估肝功能的半乳糖呼气试验（GBT）的改良方法。静脉注射每公斤体重0.5克半乳糖以及2微居里通常为14C标记的半乳糖后，在一小时内定期收集14CO2。由于呼气中的14C活性在70 - 100分钟内呈线性上升，所获得的曲线允许计算初始斜率以及45分钟后的“标准化比活性”。对8名肝脏正常者、8名酒精性肝硬化患者、4名慢性活动性肝炎（CAH）患者和6名原发性胆汁性肝硬化（PBC）患者进行了GBT检测。将结果与同时测量的半乳糖清除能力（GEC）以及溴磺酞钠（BSP）的初始血浆消失率（ki）进行比较。在肝脏正常者中，初始斜率和标准化比活性的值分别为1.08±标准差0.3和0.42±标准差0.1。相比之下，所有患者组获得的值均明显降低。CAH患者的降低最为严重；PBC患者的降低最小。GBT在肝脏正常者和肝病患者之间有很好的区分度（p＜0.001，t检验）。GBT的结果与GEC（r分别为0.86和0.87）以及BSP - ki（r分别为0.9和0.92）呈线性相关。这些结果表明，GBT可被视为一种细胞质肝功能的定量指标。
