Kleinberg M L, Stauffer G L, Latiolais C J
Am J Hosp Pharm. 1980 May;37(5):680-2.
The room temperature stabilities of repackaged pentazocine hydrochloride injection, promethazine hydrochloride injection, haloperidol oral concentrate, phenytoin oral suspension, and isoetharine inhalation solution were determined. After being repackaged as unit doses in a Hy-Pod Hypodermic Syringe, Ped-Pod Oral Dispenser, or NebuJect Nebulizer Injector (all made by MPL, Inc., SoloPak Division), several containers of each drug were stored at room temperature. Isoetharine samples were assayed after 15 and 30 days, while samples of the other drugs were assayed after 90, 180, and 360 days. Also, separate samples of pentazocine and promethazine were stored at 40, 50, and 60 degrees C and were assayed after 15, 30, and 90 days. The long-range stabilities of the drugs stored at elevated temperatures were predicted using the Arrhenius technique. The results indicate that, under the conditions tested, isoetharine can be stored for at least 30 days at room temperature and promethazine, pentazocine, haloperidol, and phenytoin can be stored for at least a year, all with less than 10% loss in potency. Arrhenius data indicate that pentazocine injection probably would be stable at room temperature for much longer than the 360 days for which it was tested.
测定了重新包装的盐酸喷他佐辛注射液、盐酸异丙嗪注射液、氟哌啶醇口服浓缩液、苯妥英口服混悬液和异丙肾上腺素吸入溶液在室温下的稳定性。将每种药物以单位剂量重新包装在Hy-Pod皮下注射器、Ped-Pod口服分配器或NebuJect雾化器注射器（均由MPL公司SoloPak分部生产）中后，每个药物的几个容器在室温下储存。异丙肾上腺素样品在15天和30天后进行分析，而其他药物的样品在90天、180天和360天后进行分析。此外，喷他佐辛和异丙嗪的单独样品在40、50和60摄氏度下储存，并在15天、30天和90天后进行分析。使用阿仑尼乌斯技术预测了在高温下储存的药物的长期稳定性。结果表明，在测试条件下，异丙肾上腺素在室温下可储存至少30天，异丙嗪、喷他佐辛、氟哌啶醇和苯妥英可储存至少一年，所有药物的效价损失均小于10%。阿仑尼乌斯数据表明，盐酸喷他佐辛注射液在室温下可能比测试的360天更稳定。
