[亲水性凝胶的抗血栓特性]
[Thromboresistent properties of hydrophilic gels].
作者信息
Chepurov A K, Belomestnaia Z M, Donetskiĭ I A, Tsidvintseva G V
出版信息
Biull Eksp Biol Med. 1980 Mar;89(3):296-8.
Thromboresistant properties of hydrophilic gels prepared on the basis of copolymers of nitrogen-containing heterocyclic vinyl compounds with vinyl monomers have been investigated. Hydrophilic gels prevent fibrinogen adsorption, activation of procoagulants and adhesion of platelets. Hydrogel surfaces possess selective tropism for plasma albumin. It is believed that the thromboresistant effect of the hydrophilic gels is consequent on the competitive action of plasma albumin. Modification of the gels leads to the improvement of their thromboresistant properties.
对基于含氮杂环乙烯基化合物与乙烯基单体的共聚物制备的亲水性凝胶的抗血栓性能进行了研究。亲水性凝胶可防止纤维蛋白原吸附、凝血因子激活和血小板黏附。水凝胶表面对血浆白蛋白具有选择性趋向性。据信亲水性凝胶的抗血栓作用是血浆白蛋白竞争作用的结果。凝胶的改性导致其抗血栓性能的改善。
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