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1
Possible role of prostaglandin E1 in the affective disorders and in alcoholism.前列腺素E1在情感障碍和酒精中毒中的可能作用。
Br Med J. 1980 Jun 7;280(6228):1363-6. doi: 10.1136/bmj.280.6228.1363.
2
A biochemical basis for alcoholism and alcohol-induced damage including the fetal alcohol syndrome and cirrhosis: interference with essential fatty acid and prostaglandin metabolism.
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3
Sjogren's syndrome and the sicca syndrome: the role of prostaglandin E1 deficiency. Treatment with essential fatty acids and vitamin C.干燥综合征与口眼干燥症：前列腺素E1缺乏的作用。用必需脂肪酸和维生素C治疗。
Med Hypotheses. 1980 Mar;6(3):225-32. doi: 10.1016/0306-9877(80)90120-6.
4
The regulation of prostaglandin E1 formation: a candidate for one of the fundamental mechanisms involved in the actions of vitamin C.前列腺素E1形成的调节：维生素C作用所涉及的基本机制之一的候选因素。
Med Hypotheses. 1979 Aug;5(8):849-58. doi: 10.1016/0306-9877(79)90075-6.
5
A new concept of lifestyle-related cardiovascular disease: the importance of interactions between cholesterol, essential fatty acids, prostaglandin E1 and thromboxane A2.生活方式相关心血管疾病的新概念：胆固醇、必需脂肪酸、前列腺素E1和血栓素A2之间相互作用的重要性。
Med Hypotheses. 1980 Aug;6(8):785-800. doi: 10.1016/0306-9877(80)90003-1.
6
Essential fatty acid supplementation inhibits the effect of dietary zinc deficiency.
Adv Prostaglandin Thromboxane Res. 1980;8:1797-8.
7
The possible roles of prostaglandin E1 and of essential fatty acids in mania, depression and alcoholism.前列腺素E1和必需脂肪酸在躁狂症、抑郁症及酒精中毒中的可能作用。
Prog Lipid Res. 1981;20:539-41. doi: 10.1016/0163-7827(81)90095-3.
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Effect of ADP on PGE1 formation in blood platelets from patients with depression, mania and schizophrenia.ADP对抑郁症、躁狂症和精神分裂症患者血小板中PGE1形成的影响。
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Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches.快速循环型外周血单个核细胞的特定发作期差异基因表达支持新的治疗方法。
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Drugs. 2004;64(23):2619-27. doi: 10.2165/00003495-200464230-00001.
3
Long-chain polyunsaturated fatty acids and eicosanoids in infants--physiological and pathophysiological aspects and open questions.婴儿体内的长链多不饱和脂肪酸和类二十烷酸——生理与病理生理方面及未解决的问题
Lipids. 1999 Feb;34(2):199-205. doi: 10.1007/s11745-999-0354-z.
4
Changes in the blood platelets of alcoholics during alcohol withdrawal.酒精戒断期间酗酒者血小板的变化。
J Clin Pathol. 1983 Mar;36(3):337-40. doi: 10.1136/jcp.36.3.337.
5
Indomethacin does not antagonize the anxiolytic action of ethanol in the elevated plus-maze.吲哚美辛不会拮抗乙醇在高架十字迷宫中的抗焦虑作用。
Psychopharmacology (Berl). 1990;101(2):203-7. doi: 10.1007/BF02244127.

本文引用的文献

1
Polyethenoid fatty acid metabolism. VI. Effect of pyridoxine on essential fatty acid conversions.聚烯脂肪酸代谢。VI. 吡哆醇对必需脂肪酸转化的影响。
Arch Biochem Biophys. 1952 Dec;41(2):266-73. doi: 10.1016/0003-9861(52)90455-4.
2
On the activity of prostaglandin-dehydrogenase system in the kidney. A histochemical study during hydration-dehydration and salt-repletion-salt-depletion.关于肾脏中前列腺素脱氢酶系统的活性。水合-脱水及补盐-缺盐过程中的组织化学研究。
Histochemie. 1969;17(3):241-7. doi: 10.1007/BF00309868.
3
Evaluation of lithium therapy in chronic and periodic alcoholism.锂疗法在慢性和周期性酒精中毒中的评估。
Am J Med Sci. 1974 Jul;268(1):15-22. doi: 10.1097/00000441-197407000-00002.
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Zinc nutrition in the United States.
Am J Clin Nutr. 1973 Nov;26(11):1251-60. doi: 10.1093/ajcn/26.11.1251.
5
Prostaglandin synthetase system--resolution into oxygenase and isomerase components.前列腺素合成酶系统——分解为加氧酶和异构酶成分。
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3645-8. doi: 10.1073/pnas.71.9.3645.
6
The oxidative desaturation of unsaturated fatty acids in animals.动物体内不饱和脂肪酸的氧化去饱和作用。
Mol Cell Biochem. 1974 Mar 8;3(1):41-52. doi: 10.1007/BF01660076.
7
A glucagonoma syndrome.一种胰高血糖素瘤综合征。
Lancet. 1974 Jul 6;2(7871):1-5. doi: 10.1016/s0140-6736(74)91343-9.
8
The long chain metabolites of linoleic avid linolenic acids in liver and brain in herbivores and carnivores.
Comp Biochem Physiol B. 1976;54(3):395-401. doi: 10.1016/0305-0491(76)90264-9.
9
Effect of ADP on PGE1 formation in blood platelets from patients with depression, mania and schizophrenia.ADP对抑郁症、躁狂症和精神分裂症患者血小板中PGE1形成的影响。
Br J Psychiatry. 1975 Dec;127:591-5. doi: 10.1192/bjp.127.6.591.
10
Physiological cortisol levels block the inhibition of vascular reactivity produced by prolactin.生理水平的皮质醇可阻止催乳素对血管反应性的抑制作用。
Endocrinology. 1976 Aug;99(2):406-10. doi: 10.1210/endo-99-2-406.

前列腺素E1在情感障碍和酒精中毒中的可能作用。

Possible role of prostaglandin E1 in the affective disorders and in alcoholism.

作者信息

Horrobin D F, Manku M S

出版信息

Br Med J. 1980 Jun 7;280(6228):1363-6. doi: 10.1136/bmj.280.6228.1363.

DOI:10.1136/bmj.280.6228.1363
PMID:7388546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1601822/
Abstract

Prostaglandin (PG)E1 may play an important part in the affective disorders, with an excess being present in mania and a deficiency in depression. Platelets from manic patients produce more PGE1 than normal while those from depressive patients produce less. Ethyl alcohol stimulates PGE1 production whereas lithium inhibits it. Alcoholics will tend to have raised PGE1 concentrations while drinking, but, because precursor supplies are limited, when alcohol concentrations fall PGE1 concentrations may fall sharply leading to depression. PGE1 biosynthesis may be affected by nutritional factors including essential fatty acids, pyridoxine, vitamin C, and zinc. Nutritional approaches may be of value in both depression and alcoholism.

摘要

前列腺素（PG）E1可能在情感障碍中起重要作用，躁狂症患者体内PGE1过量，抑郁症患者体内则缺乏。躁狂症患者的血小板产生的PGE1比正常人多，而抑郁症患者的血小板产生的PGE1较少。乙醇刺激PGE1的产生，而锂则抑制其产生。酗酒者在饮酒时PGE1浓度往往会升高，但由于前体供应有限，当酒精浓度下降时，PGE1浓度可能会急剧下降，导致抑郁。PGE1的生物合成可能受到包括必需脂肪酸、吡哆醇、维生素C和锌在内的营养因素的影响。营养疗法在抑郁症和酗酒治疗中可能都有价值。