Järhult J, Hellstrand P, Sundler F
Cell Tissue Res. 1980;207(1):55-64. doi: 10.1007/BF00239329.
Scattered vasoactive intestinal polypeptide (VIP)-immunoreactive nerves were found in the striated muscle of the hind limb of the cat, where they usually were associated with small blood vessels. VIP-immunoreactive nerves were also demonstrated in the sciatic nerve; after ligation an abundance of intensely immunoreactive VIP fibres were seen proximal to the ligation. Intraarterial infusion of VIP into isolated hind limb of the cat had dramatic effects on different sections of the vascular bed. Thus, VIP dilated the resistance vessels leading to a marked increment in muscle blood flow. VIP also relaxed the capacitance vessels causing regional pooling of blood; it increased the capillary surface area available for fluid exchange. Infusions of VIP at a dose of 8 microgram/min significantly inhibited the vasoconstriction, induced by electrical stimulation of the regional sympathetic nerves. It is suggested that local nervous release of VIP may act as a modulator of vascular tone in skeletal muscle.
在猫后肢的横纹肌中发现了散在的血管活性肠肽（VIP）免疫反应性神经，它们通常与小血管相关。在坐骨神经中也证实有VIP免疫反应性神经；结扎后，在结扎近端可见大量强免疫反应性VIP纤维。向猫的离体后肢动脉内注入VIP对血管床的不同节段有显著影响。因此，VIP使阻力血管扩张，导致肌肉血流量显著增加。VIP还使容量血管舒张，引起局部血液淤积；它增加了可用于液体交换的毛细血管表面积。以8微克/分钟的剂量注入VIP可显著抑制由局部交感神经电刺激诱导的血管收缩。提示局部神经释放的VIP可能作为骨骼肌血管张力的调节剂。
