麻醉猫中河豚毒素对延髓心血管的影响。
Medullary cardiovascular effects of tetrodotoxin in anaesthetized cats.
作者信息
Bousquet P, Feldman J, Bloch R, Schwartz J
出版信息
Eur J Pharmacol. 1980 Jul 25;65(2-3):293-6. doi: 10.1016/0014-2999(80)90404-5.
PMID:7398792
Abstract
Tetrodotoxin injected in the cat nucleus tracus solitarii produced hypertension without bradycardia, whereas in the nucleus reticularis lateralis it led to hypotension and bradycardia. Tetrodotoxin acts by blocking neuronal activity; it is a useful tool for studying the central organization of cardiovascular regulation. The present data confirm that the nucleus reticularis lateralis is a vasopressive centre.
摘要
向猫的孤束核注射河豚毒素会导致血压升高而无心动过缓，而向外侧网状核注射则会导致血压降低和心动过缓。河豚毒素通过阻断神经元活动起作用；它是研究心血管调节中枢组织的有用工具。目前的数据证实外侧网状核是一个升压中枢。
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