Gerlich W H, Lüer W, Thomssen R
J Infect Dis. 1980 Jul;142(1):95-101. doi: 10.1093/infdis/142.1.95.
IgM antibody to hepatitis B core antigen (anti-HBc) was determined by a reverse enzyme immunoassay. In all of 58 patients with transient hepatitis B surface antigen (HBsAg)-positive acute hepatitis, IgM anti-HBc was detected in high titer. In 79.3%, IgM anti-HBc disappeared within two years, but in the remaining 12, it was still detectable. In 20 of 21 patients who developed chronic hepatitis, IgM anti-HBc was present after two years. High titers of IgM anti-HBc were found in 13 patients with histologically confirmed hepatitis B in whom HBsAg could not be detected in the initial serum samples; 11 of them later developed antibody to HBsAg and/or e antigen. Furthermore, IgM anti-HGc was detected in eight (5.6%) of 142 HBsAg-negative blood donors with elevated levels of serum transaminases and in 11 (0.5%) of 2,400 HBsAg-negative blood donors with normal levels of serum transaminases. Thus, IgM anti-HBc might be a better indicator of hepatitis B than HBsAg and help differentiage acute from chronic infection in HBsAg-positive patients.
采用反向酶免疫分析法检测乙肝核心抗原IgM抗体（抗-HBc）。在58例乙肝表面抗原（HBsAg）短暂阳性的急性肝炎患者中，均检测到高滴度的IgM抗-HBc。79.3%的患者IgM抗-HBc在两年内消失，但其余12例仍可检测到。在21例发展为慢性肝炎的患者中，20例在两年后仍存在IgM抗-HBc。在13例经组织学证实为乙型肝炎但初始血清样本中未检测到HBsAg的患者中发现高滴度的IgM抗-HBc；其中11例后来产生了抗-HBsAg和/或e抗原抗体。此外，在142例血清转氨酶水平升高的HBsAg阴性献血者中有8例（5.6%）检测到IgM抗-HBc，在2400例血清转氨酶水平正常的HBsAg阴性献血者中有11例（0.5%）检测到IgM抗-HBc。因此，IgM抗-HBc可能是比HBsAg更好的乙肝指标，有助于区分HBsAg阳性患者的急性感染和慢性感染。
