Nosova L G, Potin V V, Khramtsova V Ia
Probl Endokrinol (Mosk). 1980 May-Jun;26(3):3-6.
A test with intramuscular injection of 5 or 10 U of TTH was carried out in 47 patients suffering from diffuse toxic goiter, including 34 cases at the stage of thyrotoxicosis remission. Results of this test were evaluated by the changes of I131 absorption by the thyroid gland and of the blood protein-bound iodine level. The thyroid gland TTH sensitivity was found to be diminished in 16 patients with thyrotoxicosis remission. The reaction was absent most regularly in patients with ophthalmopathy. This denotes a latent form of thyroid insufficiency and suggest that the patients with the negative response to the exogenous TTH are in the "risk group" in respect to the development of manifest hypothyroidism.
对47例弥漫性毒性甲状腺肿患者进行了肌肉注射5或10单位促甲状腺素(TTH)的试验,其中包括34例处于甲状腺毒症缓解期的患者。通过甲状腺对I131的摄取及血中蛋白结合碘水平的变化来评估该试验结果。发现16例处于甲状腺毒症缓解期的患者甲状腺对TTH的敏感性降低。在伴有眼病的患者中,该反应最常缺失。这表明存在潜在的甲状腺功能不全形式,并提示对外源性TTH反应阴性的患者在发生明显甲状腺功能减退方面属于“风险组”。