Proudfit W L, Bruschke V G, Sones F M
Circulation. 1980 Oct;62(4):712-7. doi: 10.1161/01.cir.62.4.712.
The clinical course was followed for 10 years in 521 patients whose coronary arteriograms did not show any severe obstruction. Coronary disease had been suspected in all patients before arteriography. Two of 357 patients thought to have normal arteriograms died from coronary disease and two of 101 patients died who had less than 30% estimated narrowing of at least one coronary artery. Ten deaths ascribed to coronary disease occurred in 63 patinets who had 30-50% narrowing of at least one major coronary artery. The difference in death rates between the normal or mildly diseased groups and the group that had moderate narrowing was significant (p < 0.01). Coronary events (death from coronary disease, subsequent myocardial infarction, or arteriographic evidence of progression of coronary obstruction) occurred in 2.1% of those who had normal arteriograms, 13.8% of the group with mild lesions, and 33% of those with moderate degree of coronary arterial narrowing.
对521例冠状动脉造影未显示任何严重阻塞的患者进行了为期10年的临床随访。在血管造影之前，所有患者均被怀疑患有冠状动脉疾病。357例被认为血管造影正常的患者中有2例死于冠状动脉疾病，101例估计至少有一支冠状动脉狭窄小于30%的患者中有2例死亡。在63例至少有一支主要冠状动脉狭窄30%-50%的患者中，有10例死于冠状动脉疾病。正常或轻度病变组与中度狭窄组的死亡率差异具有显著性（p<0.01）。冠状动脉事件（死于冠状动脉疾病、随后发生心肌梗死或冠状动脉阻塞进展的血管造影证据）在血管造影正常的患者中发生率为2.1%，轻度病变组为13.8%，冠状动脉中度狭窄组为33%。
