Weir E K, Matisonn R E, Losman E, Chesler E
S Afr Med J. 1978 Oct 21;54(17):700-2.
Infants with pulmonary atresia are frequently dependent upon the patency of the ductus arteriosus for adequate pulmonary blood flow. Endogenous production of a dilator prostaglandin probably maintains patency of the ductus in utero. Infusion of prostaglandin E1 (PGE1) 0,1 microgram/kg/min was used in 6 infants with pulmonary atresia to increase pulmonary blood flow and systemic oxygenation. The infusion improved the clinical condition of the infants and diminished the degree of central cyanosis. In 3 cases serial measurement of systemic arterial oxygen tension showed a sustained increase. There were no deleterious side-effects. During cardiac catheterization and preparation for operation, PGE1 provides a valuable means of maintaining pulmonary blood flow in infants with pulmonary atresia and a ductus arteriosus.
患有肺动脉闭锁的婴儿常常依赖动脉导管的通畅来获得充足的肺血流。扩张性前列腺素的内源性产生可能在子宫内维持动脉导管的通畅。对6例患有肺动脉闭锁的婴儿使用每分钟0.1微克/千克的前列腺素E1（PGE1）输注，以增加肺血流和全身氧合。输注改善了婴儿的临床状况并减轻了中心性发绀的程度。在3例病例中，连续测量体动脉血氧张力显示持续升高。没有有害的副作用。在心脏导管插入术和手术准备期间，PGE1为维持患有肺动脉闭锁和动脉导管的婴儿的肺血流提供了一种有价值的方法。
