Janghorbani M, Young V R
Am J Clin Nutr. 1980 Sep;33(9):2021-30. doi: 10.1093/ajcn/33.9.2021.
Use of stable isotopes to determine bioavailability of minerals, by the method of fecal monitoring, in human diets is discussed. Analytical expressions are developed to permit prediction of the accuracy of the method as a function of several variables involved. The effects of extent of absorption, natural abundance of the selected isotope, and the enrichment ratio of administered diet on the accuracy of the estimate of absorption are examined. the method of neutron activation analysis as applied to the isotopic measurement of trace minerals including iron, zinc, copper, chromium, and nickel is briefly discussed. The method of fecal monitoring for zinc and iron is illustrated with data obtained in a healthy adult subject receiving a diet enriched with 70Zn and 58Fe.
本文讨论了通过粪便监测法，利用稳定同位素测定人类饮食中矿物质生物利用率的方法。推导了分析表达式，以便根据所涉及的几个变量预测该方法的准确性。研究了吸收程度、所选同位素的天然丰度以及所给予饮食的富集率对吸收估计准确性的影响。简要讨论了应用于包括铁、锌、铜、铬和镍在内的微量矿物质同位素测量的中子活化分析方法。通过在一名接受富含(^{70}Zn)和(^{58}Fe)饮食的健康成年受试者中获得的数据，说明了锌和铁的粪便监测方法。
