Bloch-Morot E, Lebel B, Burtin C, Sabine M C, Burtin P
Ann Immunol (Paris). 1977 Nov-Dec;128(6):979-84.
Leucocytes challenged with anti-NCA serum (non-specific cross-reacting antigen) can release histamine. This release is Ca++, glucose and temperature dependent as usually described for basophils. Only half of the subjects whose basophils can release histamine when challenged with anti-IgE serum are also able to release histamine with anti-NCA serum. There is no cross-reaction between IgE and anti-NCA serum or between NCA and anti-IgE serum. So it seems likely that NCA might be a marker on the surface of some human basophils.
用抗NCA血清(非特异性交叉反应抗原)刺激白细胞可释放组胺。这种释放如通常所述的嗜碱性粒细胞一样,依赖于钙离子、葡萄糖和温度。在用抗IgE血清刺激时嗜碱性粒细胞能释放组胺的受试者中,只有一半也能用抗NCA血清释放组胺。IgE与抗NCA血清之间或NCA与抗IgE血清之间不存在交叉反应。因此,NCA似乎可能是某些人类嗜碱性粒细胞表面的一种标志物。