关于β,β'-亚氨基二丙腈（IDPN）处理的卤虫（卤虫）的药理学和行为学研究

A pharmacological and behavioural study on beta, beta'-iminodipropionitrile (IDPN)-treated brine shrimp Artemia salina L.

作者信息

Schott K, Schneider G, Oepen H

出版信息

Toxicol Lett. 1980 Sep;6(4-5):231-4. doi: 10.1016/0378-4274(80)90124-1.

Abstract

The neurotoxic substance beta, beta-iminodipropionitrile (IDPN), which induces hyperkinesia in some mammals, was found to be neurotoxic to the brine shrimp Artemia salina L. (Crustacea, Anostraca) inducing discoordination of limb-movement and sedation of motility. Up to 9 metabolities of IDPN were detected in Artemia, including beta-alanine, cyanoacetic acid, and beta-aminopropionitrile (BAPN). Brine shrimp, especially nauplius (1 day), may be a useful test animal for the biological assay of IDPN.

摘要

神经毒性物质β，β-亚氨基二丙腈（IDPN）可在某些哺乳动物中诱发运动亢进，现已发现其对卤虫（甲壳纲，无甲目）具有神经毒性，可导致卤虫肢体运动失调和运动迟缓。在卤虫体内检测到多达9种IDPN的代谢产物，包括β-丙氨酸、氰基乙酸和β-氨基丙腈（BAPN）。卤虫，尤其是无节幼体（1日龄），可能是用于IDPN生物测定的有用实验动物。