在环境温度升高条件下饲养的家兔体温调节反应的改变。
Modification of thermoregulatory responses in rabbits reared at elevated environmental temperatures.
作者信息
Cooper K E, Ferguson A V, Veale W L
出版信息
J Physiol. 1980 Jun;303:165-72. doi: 10.1113/jphysiol.1980.sp013278.
Abstract
- Pregnant New Zealand white rabbits were kept from 14 days pre-partum at an environmental temperature of 33 degrees C, and their offspring were reared at this temperature. 2. In response to a 4 hr cold exposure, animals (aged 90-180 days) raised in this way showed significant drops in colonic temperature (-2.7 +/- 0.5 degrees C) while control animals reared at 20 degrees C did not (+0.05 +/- 0.1 degrees C). 3. A reduced, monophasic endotoxin fever was observed in animals reared at 33 degrees C, while a normal biphasic fever was seen in rabbits originally reared at 20 degrees C and subsequently acclimated to 33 degrees C. 4. A greatly reduced temperature response to intravenous infusion of noradrenaline was also found in animals raised at 33 degrees C. 5. It is proposed that thermal afferent input during early life may play an important role in the development of the thermoregulatory system.
摘要
- 将怀孕的新西兰白兔在产前14天置于33摄氏度的环境温度下饲养，其后代也在此温度下饲养。2. 作为对4小时冷暴露的反应，以这种方式饲养的动物（90 - 180日龄）结肠温度显著下降（-2.7 +/- 0.5摄氏度），而在20摄氏度下饲养的对照动物则没有下降（+0.05 +/- 0.1摄氏度）。3. 在33摄氏度下饲养的动物中观察到内毒素热反应减弱且呈单相，而最初在20摄氏度下饲养、随后适应33摄氏度的兔子则出现正常的双相热反应。4. 在33摄氏度下饲养的动物中，对静脉注射去甲肾上腺素的温度反应也大大降低。5. 有人提出，生命早期的热传入输入可能在体温调节系统的发育中起重要作用。
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