地高辛对营养不良小鼠骨骼肌静息膜电位的影响。

The effects of digoxin on resting membrane potentials of skeletal muscles in dystrophic mice.

作者信息

Saito K, Ohkura H, Tanaka H, Kashima T, Katanasako H, Kanehisa T

出版信息

Jpn J Exp Med. 1980 Jun;50(3):179-82.

Abstract

To clarify the abnormality of skeletal muscles in dystrophic mice, we studied the potassium content, resting membrane potential and especially the effects of digoxin on the membrane potential. Both the potassium content and the resting membrane potential of dystrophic muscles were significantly lower than those of normal mice. The resting membrane potential of dystrophic muscles was less reduced by digoxin than that of normal mice. It was suggested that there was a change in membrane permeability of skeletal muscles in dystrophic mice and that membrane permeability was less sensitive to digoxin than normal mice.

摘要

为了阐明营养不良小鼠骨骼肌的异常情况，我们研究了钾含量、静息膜电位，尤其是地高辛对膜电位的影响。营养不良小鼠肌肉的钾含量和静息膜电位均显著低于正常小鼠。地高辛对营养不良小鼠肌肉静息膜电位的降低作用小于对正常小鼠的作用。这表明营养不良小鼠骨骼肌的膜通透性发生了变化，且膜通透性对地高辛的敏感性低于正常小鼠。