Srikantaiah M V, Lew D W, Morin R J
Lipids. 1980 Aug;15(8):555-8. doi: 10.1007/BF02534178.
The conversion of 3H-squalene to sterols by rat liver microsomes and cytosol was inhibited by individual rat and human plasma lipoproteins at various concentrations. This inhibition was also observed with added human high density apolipoprotein, but triglycerides, cholesterol, or cholesteryl esters had no inhibitory effects. Lipoproteins and apo high density lipoprotein (HDL) were demonstrated to bind 3H-squalene in vitro. The binding of 3H-squalene by apo HDL could be reversed by increasing concentration of liver cytosol containing sterol carrier protein.
大鼠肝脏微粒体和胞液将3H-角鲨烯转化为甾醇的过程受到不同浓度的大鼠和人血浆脂蛋白的抑制。添加人高密度载脂蛋白时也观察到这种抑制作用，但甘油三酯、胆固醇或胆固醇酯没有抑制作用。脂蛋白和载脂蛋白高密度脂蛋白（HDL）在体外被证明能结合3H-角鲨烯。通过增加含甾醇载体蛋白的肝脏胞液浓度，载脂蛋白HDL对3H-角鲨烯的结合作用可以被逆转。
