[Effects of uncouplers on the phospholipid composition of mitochondria].
作者信息
Kargapolov A V, Iaguzhinskiĭ L S
出版信息
Biokhimiia. 1978 Dec;43(12):2150-3.
PMID:743509
Abstract
A decrease in the level of lysocardiolipin and lysophosphatidylethanolamine in mitochondria induced by chlorophenacyl and 2,4-dinitrophenol was demonstrated. The effects of the uncouplers were especially well-pronounced under conditions of mitochondrial swelling. It was found that the phospholipase inhibitor nupercain completely reverses the effects. The data obtained suggest that 2,4-dinitrophenol and alkylating compounds increase the phospholipase activity of mitochondria under given experimental conditions.
摘要
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