McKinney L A, Hendricks L D
Am J Trop Med Hyg. 1980 Sep;29(5):753-60. doi: 10.4269/ajtmh.1980.29.753.
Thirty-four Mystromys albicaudatus were injected intradermally with Leishmania braziliensis promastigotes and examined and killed during a 12-week period. All animals developed single cutaneous lesions at the sites of inoculation that began as a papular thickening in the dermis and progressed to a 2.0 cm crateriform ulcer. The histopathology of these lesions was characterized by granuloma formation and diffuse infiltrates of lymphocytes and plasma cells. Parasites were most frequently observed in vacuolated macrophages immediately underlying the necrotic debris of the ulcer. Histiocytes in which amastigotes were not identified were noted in aggregates at the margins of the inflammation. Russell's bodies were observed at 6 weeks post-infection, and discrete lymphocytic infiltrates bordered the inflammation at 12 weeks post-infection. It is suggested that M. albicaudatus is an excellent model of American cutaneous leishmaniasis.
将34只白尾匙鼠皮内注射巴西利什曼原虫前鞭毛体，并在12周内进行检查和处死。所有动物在接种部位都出现了单个皮肤病变，开始时为真皮内的丘疹样增厚，随后发展为直径2.0厘米的火山口状溃疡。这些病变的组织病理学特征为肉芽肿形成以及淋巴细胞和浆细胞的弥漫性浸润。在溃疡坏死碎片下方紧邻的空泡化巨噬细胞中最常观察到寄生虫。在炎症边缘可见聚集的未发现无鞭毛体的组织细胞。感染后6周观察到拉塞尔小体，感染后12周离散的淋巴细胞浸润围绕炎症。提示白尾匙鼠是美洲皮肤利什曼病的优良模型。
