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牛对溶血巴斯德氏菌的肺部反应研究:肺巨噬细胞反应。

Study of bovine pulmonary response to Pasteurella haemolytica: pulmonary macrophage response.

作者信息

Walker R D, Corstvet R E, Panciera R J

出版信息

Am J Vet Res. 1980 Jul;41(7):1008-14.

PMID:7436096
Abstract

A resistance state was produced in the bovine lung by exposing calves to an aerosolized mist of Pasteurella haemolytica. Verification of the resistant state was determined by an increase in clearance of P haemolytica from lungs of exposed calves vs lungs from nonexposed calves over 24 hours. Bovine pulmonary macrophages isolated from lung washings of calves exposed to P haemolytica and from lungs of nonexposed calves failed to phagocytize P haemolytica in vitro. Whole serum, pulmonary immunoglobulin (Ig) A, and IgG from exposed and nonexposed calves did not enhance phagocytosis as measured by 14C uptake or fluorescent antibody staining.

摘要

通过让小牛接触溶血巴斯德菌的雾化喷雾,在牛肺中产生了一种抵抗状态。通过比较暴露小牛肺部与未暴露小牛肺部在24小时内溶血巴斯德菌清除率的增加来确定抵抗状态的验证。从暴露于溶血巴斯德菌的小牛肺灌洗物和未暴露小牛的肺中分离出的牛肺巨噬细胞在体外不能吞噬溶血巴斯德菌。通过14C摄取或荧光抗体染色测量,来自暴露和未暴露小牛的全血清、肺免疫球蛋白(Ig)A和IgG均未增强吞噬作用。

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