溶血性疾病中红细胞生成的定量评估。
Quantitative assessment of erythropoiesis in haemolytic disease.
作者信息
Stefanelli M, Barosi G, Cazzola M, Orlandi E
出版信息
Br J Haematol. 1980 Jun;45(2):297-308. doi: 10.1111/j.1365-2141.1980.tb07149.x.
Erythrokinetic parameters were estimated in 21 patients suffering from haemolytic disease using a mathematical model of iron kinetics. A proper definition of radioiron reflux from red cells to the plasma proved to be essential for an accurate estimate of effective and ineffective erythropoiesis in severe haemolytic conditions. Erythropoietic activity was increased in all the patients, with the marrow capable of sustaining erythropoiesis at about 6 times normal in hereditary spherocytosis and 3 times normal in autoimmune haemolytic anaemia. This proliferative effort was countered by an increase in ineffective erythropoiesis which was especially marked in hereditary spherocytosis.
利用铁动力学数学模型，对21例溶血性疾病患者的红细胞生成动力学参数进行了估算。事实证明，对放射性铁从红细胞反流至血浆进行恰当定义，对于准确估算严重溶血状态下的有效和无效红细胞生成至关重要。所有患者的红细胞生成活性均增强，在遗传性球形红细胞增多症中，骨髓维持红细胞生成的能力约为正常水平的6倍，在自身免疫性溶血性贫血中约为正常水平的3倍。这种增殖作用被无效红细胞生成的增加所抵消，这在遗传性球形红细胞增多症中尤为明显。
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