Chindasilpa V, Schauf V, Hamilton L R, Riff L J
Dev Pharmacol Ther. 1980;1(4):238-53.
40 newborn infants and children were treated with netilmicin. With a 2-mg/kg dose, the average peak serum concentration was 4.4 microgram/ml. Serum concentrations resulting from the first dose were markedly lower than subsequent doses and therapeutically inadequate. Significant drug accumulation did not occur: peak and trough concentrations on days 2 and 7 were the same in patients with normal renal function. The half-life of netilmicin in infants less than 1 week old was 3.8 h in infants older than 1 week. Infants less than 7 days old require a prolonged dose interval (12 h) to adequately clear the administered dose. Recovery of netilmicin in urine ranged from 50 to 100% and correlated with age and duration of treatment. Elimination of netilmicin was prolonged in newborn infants with renal failure and requires dosage adjustment. Transient change in creatinine clearance occurred in 2 patients (4.6%) and ototoxicity was observed on 2 other patients.
40名新生儿和儿童接受了奈替米星治疗。剂量为2mg/kg时，血清平均峰值浓度为4.4微克/毫升。首剂后的血清浓度明显低于后续剂量，且治疗效果不佳。未出现明显的药物蓄积：肾功能正常的患者在第2天和第7天的峰值和谷值浓度相同。1周龄以下婴儿的奈替米星半衰期为3.8小时，1周龄以上婴儿的半衰期更长。7日龄以下婴儿需要延长给药间隔时间（12小时）以充分清除给药剂量。尿中奈替米星的回收率在50%至100%之间，且与年龄和治疗持续时间相关。肾衰竭新生儿的奈替米星消除时间延长，需要调整剂量。2例患者（4.6%）出现肌酐清除率短暂变化，另有2例患者观察到耳毒性。
