Sellakumar A R, Laskin S, Kuschner M, Rusch G, Katz G V, Snyder C A, Albert R E
J Environ Pathol Toxicol. 1980 Aug;4(1):107-15.
The comparative carcinogenicity of dimethylcarbamoyl chloride (DMCC) was studies in male, Syrian Golden Hamsters by inhalation. Hamsters were exposed to 1ppm and the exposure periods were 6 hours per day, 5 days per week for the lifetime of the animals. Fifty-one percent of the hamsters developed carcinomas of the nasal tract. Morphologically, all of these tumors were classified as squamous cell carcinomas. In comparing the response of rats and hamsters at 1 ppm DMCC, the rat seems to show increased sensitivity and the percentage of tumor yield is almost doubled, with the tumors appearing much earlier in rats than in hamsters. However, the remarkable tumor yield in both species indicates the potent carcinogenic effects of DMCC.
通过吸入方式，对雄性叙利亚金仓鼠进行了二甲基甲酰氯（DMCC）的比较致癌性研究。仓鼠暴露于1ppm的环境中，暴露期为动物一生，每天6小时，每周5天。51%的仓鼠发生了鼻腔癌。从形态学上看，所有这些肿瘤均被归类为鳞状细胞癌。在比较大鼠和仓鼠在1ppm DMCC环境下的反应时，大鼠似乎表现出更高的敏感性，肿瘤发生率几乎翻倍，且大鼠的肿瘤出现时间比仓鼠早得多。然而，两个物种中显著的肿瘤发生率均表明了DMCC的强大致癌作用。
