[Characteristics of lipoprotein metabolic disorders during treatment with oral contraceptives].

It has been shown in rat experiments that ethinyl estradiol and estradiol dipropionate increase hepatic biosynthesis of phospholipids, free fatty acids and their esterification to form mono-, di- and triglycerides. Cholesterol biosynthesis is enhanced only by ethinyl estradiol. The specific radioactivity of VLDL- and HLD-apoproteins increases in plasma. This is the result of enhanced lipoprotein formation and secretion. Injections of ethinyl estradiol to rats lead to less pronounced metabolic disturbances compared to those induced by the action of estradiol dipropionate. The activating effect of ethinyl estradiol on hepatic lipoprotein biosynthesis is one of the pathogenetic events of hyperlipoproteinemia development.