Titov V N, Sanfirova V M, Khodakova T D
Farmakol Toksikol. 1980 May-Jun;43(3):345-8.
It has been shown in rat experiments that ethinyl estradiol and estradiol dipropionate increase hepatic biosynthesis of phospholipids, free fatty acids and their esterification to form mono-, di- and triglycerides. Cholesterol biosynthesis is enhanced only by ethinyl estradiol. The specific radioactivity of VLDL- and HLD-apoproteins increases in plasma. This is the result of enhanced lipoprotein formation and secretion. Injections of ethinyl estradiol to rats lead to less pronounced metabolic disturbances compared to those induced by the action of estradiol dipropionate. The activating effect of ethinyl estradiol on hepatic lipoprotein biosynthesis is one of the pathogenetic events of hyperlipoproteinemia development.
大鼠实验表明，炔雌醇和二丙酸雌二醇可增加肝脏磷脂、游离脂肪酸的生物合成及其酯化作用，以形成单酯、二酯和三酯。只有炔雌醇能增强胆固醇的生物合成。血浆中极低密度脂蛋白（VLDL）和高密度脂蛋白（HLD）载脂蛋白的比放射性增加。这是脂蛋白形成和分泌增强的结果。与二丙酸雌二醇作用相比，给大鼠注射炔雌醇引起的代谢紊乱不那么明显。炔雌醇对肝脏脂蛋白生物合成的激活作用是高脂蛋白血症发生的致病因素之一。
