急性和慢性乙醇摄入后的多巴胺代谢与受体功能

Dopamine metabolism and receptor function after acute and chronic ethanol.

作者信息

Reggiani A, Barbaccia M L, Spano P F, Trabucchi M

出版信息

J Neurochem. 1980 Jul;35(1):34-7. doi: 10.1111/j.1471-4159.1980.tb12486.x.

DOI:10.1111/j.1471-4159.1980.tb12486.x

Abstract

Acute ethanol treatment in rats elicits a selective increase in dihydroxyphenylacetic acid (DOPAC) content in striatum. In contrast, striatal DOPAC concentration does not differ from normal values after chronic ethanol treatment. Chronic administration of ethanol however causes a selective increase of specific [3H]spiroperidol binding and met-enkephalin content in the striatum. Kinetic analysis of [3H]spiroperidol binding data shows that after chronic ethanol treatment there is a significant increase in the affinity constant rather than in the number of binding sites for the ligand. Our results support the hypothesis that dopaminergic mechanisms at both pre- and postsynaptic level may be involved in the mediation of some of the central effects observed after ethanol consumption.

摘要

对大鼠进行急性乙醇处理会导致纹状体中二羟基苯乙酸（DOPAC）含量选择性增加。相比之下，慢性乙醇处理后纹状体中DOPAC浓度与正常值无差异。然而，长期给予乙醇会导致纹状体中特异性[3H]螺哌啶结合和甲硫氨酸脑啡肽含量选择性增加。对[3H]螺哌啶结合数据的动力学分析表明，慢性乙醇处理后，配体的亲和力常数显著增加，而非结合位点数量增加。我们的结果支持这样一种假说，即突触前和突触后水平的多巴胺能机制可能参与介导乙醇摄入后观察到的一些中枢效应。