4-羟基环磷酰胺/醛磷酰胺的体外代谢 - Suppr

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Metabolism of 4-hydroxycyclophosphamide/aldophosphamide in vitro.

作者信息

Domeyer B E, Sladek N E

出版信息

Biochem Pharmacol. 1980 Nov 1;29(21):2903-12. doi: 10.1016/0006-2952(80)90035-0.

DOI:10.1016/0006-2952(80)90035-0

PMID:7458944

Abstract

摘要

相似文献

Metabolism of 4-hydroxycyclophosphamide/aldophosphamide in vitro.4-羟基环磷酰胺/醛磷酰胺的体外代谢

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Inhibition by cyanamide of 4-hydroxycyclophosphamide/aldophosphamide oxidation to carboxyphosphamide.

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Kinetic characterization of the catalysis of "activated" cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases.小鼠肝脏醛脱氢酶催化“活化”环磷酰胺（4-羟基环磷酰胺/醛磷酰胺）氧化为羧基磷酰胺的动力学特性研究。

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Studies on the selective action of cyclophosphamide (NSC-26271): Inactivation of the hydroxylated metabolite by tissue-soluble enzymes.环磷酰胺（NSC - 26271）的选择性作用研究：组织可溶性酶对羟基化代谢物的失活作用

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The enzymatic basis of the selective action of cyclophosphamide.环磷酰胺选择性作用的酶学基础。

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Nonlinear pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation.接受大剂量化疗后继以自体骨髓移植的转移性乳腺癌患者中环磷酰胺及4-羟基环磷酰胺/醛磷酰胺的非线性药代动力学

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Pharmacokinetics of cyclophosphamide (CP) and 4-OH-CP/aldophosphamide in systemic vasculitis.环磷酰胺（CP）及4-羟基环磷酰胺/醛磷酰胺在系统性血管炎中的药代动力学

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Half-life of oxazaphosphorines in biological fluids.生物体液中氮杂磷三环类化合物的半衰期。

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Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysis.双功能催化介导4-氢过氧环磷酰胺和4-羟基环磷酰胺转化为磷酰胺芥和丙烯醛。

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Relative contribution of human erythrocyte aldehyde dehydrogenase to the systemic detoxification of the oxazaphosphorines.人红细胞醛脱氢酶对恶唑磷类药物全身解毒的相对贡献。

Drug Metab Dispos. 1997 Dec;25(12):1436-41.

引用本文的文献

A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients.一种基于机制的乳腺癌患者环磷酰胺自身诱导的药代动力学-酶模型。

Br J Clin Pharmacol. 1999 Nov;48(5):669-77. doi: 10.1046/j.1365-2125.1999.00090.x.

Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokinetic study.

Cancer Chemother Pharmacol. 1984;12(3):167-72. doi: 10.1007/BF00256539.

Increased toxicity of the antitumor drug cyclophosphamide in mice in the presence of the volatile anesthetic agent halothane.在挥发性麻醉剂氟烷存在的情况下，抗肿瘤药物环磷酰胺对小鼠的毒性增加。

Cancer Chemother Pharmacol. 1986;16(1):35-42. doi: 10.1007/BF00255283.

Detoxifying enzymes in human ovarian tissues: comparison of normal and tumor tissues and effects of chemotherapy.人卵巢组织中的解毒酶：正常组织与肿瘤组织的比较及化疗的影响

J Cancer Res Clin Oncol. 1990;116(4):379-83. doi: 10.1007/BF01612921.

Cyclophosphamide metabolism in the primary immune organs of the chick: assays of drug activation, P450 expression, and aldehyde dehydrogenase.环磷酰胺在雏鸡主要免疫器官中的代谢：药物活化、细胞色素P450表达及醛脱氢酶的测定

Arch Toxicol. 1991;65(1):32-8. doi: 10.1007/BF01973500.

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